TACT - TREAT-NMD Advisory Committee for Therapeutics
The aim of TREAT-NMD Advisory Committee for Therapeutics (TACT) is to provide transparent and consistent guidance and advice to the neuromuscular community, in an educational and directional context, on the readiness of drugs and/or therapeutic targets for trials in neuromuscular diseases.
Cristina Csimma (Virdante Pharmaceuticals Inc), as TACT chair, is leading this exciting initiative with the support of the TACT core, nominated committee members and the TREAT-NMD secretariat. TREAT-NMD is confident that the breadth and calibre of the international TACT experts will ensure the quality of the output.
Further details of TACT members and the various applications TACT have reviewed are available in the dedicated TACT section.
| Core TACT Members | ||
| Member | Role within TACT | Affiliation |
| Cristina Csimma | Chair | Vice President, Drug Development, Virdante Pharmaceuticals Inc, Cambridge, MA, USA |
| Didier Caizergues | Regulatory | Head of the Regulatory Affairs Department at GENETHON, France. |
| Petra Kaufmann | Clinical Representative | Assistant Professor of Neurology, Columbia University, USA |
| Rudolf Korinthenberg | Clinical Representatives | Head of the Department of Neuropediatrics and Muscular Disorders at Children’s Hospital, University Hospital Freiburg |
| John McCall | Toxicology Expert | Senior Consultant, PharmaMacLLC, USA |
| D. Elizabeth McNeil | Regulatory Expert | Medical Officer, Food and Drug Administration, Rockville Maryland, USA |
| Jerry Mendell | Clinical Representative | Director, Center for Gene Therapy, Columbus Children’s Research Institute, Professor of Pediatrics and Neurology, Ohio State, University, USA. |
| Kanneboyina Nagaraju | Preclinical Expert | Associate Professor of Pediatrics, Children's National Medical Center, Washington DC, USA. |
| Dominic Wells | Preclinical Expert | Head of Department of Cellular and Molecular Neuroscience, Imperial College, London, UK |
| Extended Committee Members | ||
| Gunnar Buyse | Preclinical Expert | Associate Professor of Pediatrics & Child Neurology, School of Medicine, Leuven University, Belgium |
| Annamaria De Luca | Preclinical Expert | Professor, Department of Pharmacobiology, University of Bari, Italy |
| Miranda Grounds | Preclinical Expert | Professor, The University of Western Australia, Crawley, Australia |
| Eric Hoffman | Preclinical Expert | Director, Research Center for Genetic Medicine & The Wicker Project for Muscular Dystrophy Research, Children's National Medical Center |
| Jill Jarecki | Preclinical Expert | Research Director, Families of SMA, USA |
| Jean-Marc Raymackers | Preclinical Expert | Lecturer, Université Catholique de Louvain, Belgium |
| Meg Winberg | Preclinical Expert | Director, Discovery Research Member, Spinal Muscular Atrophy Foundation, USA |
| Mike Pleiss | Pharmacology Expert | Pharmaceutical Research and Development Executive, Mike Pleiss and Associates, LLC, USA |
| Urs Ruegg | Pharmacology Expert | Professor of Pharmacology and head of Laboratory of Pharmacology, University of Geneva, Geneva |
| Jon Tinsley | Pharmacology Expert | Senior Director, Therapeutics Programmes, Summit plc. UK |
| Avital Cnaan | Statistical Advice | Director, Multi-Center Studies Section, Center for Clinical and Community Research, Children’s National Medical Centre |
| Dieter Hauschke | Statistical Advice | Senior statistician, and Scientist at University Medical Center, Freiburg |
| Michael McDermott | Statistical Advice | Associate Chair, Associate Professor of Biostatistics and Associate Professor of Neurology, University of Rochester, Dept of Biostatistics and Computational Biology. |
| Corrado Angelini | Clinical Representative | Director Neurology Residency Program, University of Padova, Italy |
| Ed Connor | Clinical Representative | Director, Office of Investigational Therapeutics, Children’s National Medical Center, Washington, USA |
| Richard Finkel | Clinical Representative | Director, Neuromuscular Program, Childrens Hospital Philadelphia, PA, USA |
| Kenneth Fischbeck | Clinical Representative | Chief, Neurogenetics Branch, NINDS, NIH, Bethesda, MD, USA |
| Kevin Flanigan | Clinical Representative | Adjunct Associate Professor, University of Utah School of Medicine, Department of Pediatrics, Salt Lake City, UT, USA |
| Pascal Laforêt | Clinical Representative | Consultant Neurologist at Pitié-Salpêtrière Hospital, France |
| Oscar Henry Mayer | Clinical Representative | Medical Director, Pulmonary Function Testing Laboratory, Children's Hospital of Philadelphia, PA, USA |
| Monique Ryan | Clinical Representative | Paediatric Neurologist, The Royal Children’s Hospital, Victoria, Australia |
| Jeff Towbin | Clinical Representative | Director of Cardiology and Co-Director of Heart Institute at Cincinnati Children's Hospital |
| Jan Verschuuren | Clinical Representative | Head of Neuromuscular Section, Department of Neurology, Leiden University Medical Center |
| Marianne de Visser | Clinical Representative | Professor, Academic Medical Centre, Department of Neurology, Amsterdam |
| Thomas Voit | Clinical Representative | Professor of Pediatrics, Scientific and Medical Director, Institut de Myologie, France |
| Kathryn Wagner | Clinical Representative | Associate Professor of Neurology, Department of Neurology, The Johns Hopkins Hospital, Baltimore, USA |
| Maggie Walter | Clinical Representative | Assistant Professor for Neurology, Friedrich-Baur-Institute, Munich, Germany |
| Brenda Wong | Clinical Representative | Director Pediatric Neuromuscular Program and MDA Clinic, Division of Neurology, Cincinnati Children’s Hospital Medical Center, USA |
| Michelle Eagle | Physical Therapist Representative | Consultant Physiotherapist - PhD MSc MCSP, Newcastle University, UK |
| Pat Furlong | Patient Organisation Representation | CEO, Parent Project Muscular Dystrophy (PPMD), US |
| Marie-Christine Ouillade | Patient Organisation Representation | Board of Directors, AFM, France |
| Christoph Rehmann-Sutter | Ethical Input | Professor of Theory and Ethics in Biosciences, University of Lübeck, Germany |
| Nick Catlin | Patient Organisation Representation | CEO, Action Duchenne, UK |
| Beatrice de Montleau | Patient Organisation Representation | Board of Directors, AFM, France |
| Marita Pohlschmidt | Patient Organisation Representation | Director of Research, Muscular Dystrophy Campaign (MDC), UK |
| Elizabeth Vroom | Patient Organisation Representation | Chair, United Parent Project Muscular Dystrophy (UPPMD), The Netherlands / Europe |
| Secretariat | ||
| Kate Bushby | Secretariat | Professor of Neuromuscular Genetics, Newcastle University, UK |
| Emma Heslop | Secretariat | TREAT-NMD Assistant Project Manager |
| Volker Straub | Secretariat | Professor of Neuromuscular Genetics, Newcastle University, UK |
Further details of TACT members and the various applications TACT have reviewed are available in the dedicated TACT section.
