Philippe Gailly

Professor of Physiology

Universite Catholique de Louvain

Philippe Gailly

For ten years, the laboratory of cell physiology has focused on quantitative analysis of functional disorders resulting from the lack of dystrophin in murine models of DMD, using a battery of functional tests to evaluate the benefits of various therapeutic attempts, mostly gene therapy, through gene transfer with viral vectors and transgenesis.

We developed different tests for analysis of the mechanical properties of dystrophin-lacking muscles, and introduced the most specific test of eccentric contractions. Our present research focuses on intracellular calcium homeostasis in muscle and non muscle cells. In particular, our team studies the properties of TRP ion channels and their role in apoptosis, in muscle development and in DMD (implication of calpain proteases).