BIOIMAGE-NMD

BIOIMAGE-NMD

The overarching objective of the BIOIMAGE-NMD project was to deliver combined structural and molecular imaging biomarkers with proven utility for the detection of therapeutic effects in patients with rare neuromuscular diseases (NMD).

The project had three specific objectives:

  1. To develop a new generation of muscle diffusion Magnetic Resonance Imaging (MRI). This diffusion imaging technology will be used to augment a state of the art simultaneous MRI / Magnetic Resonance Spectroscopic Imaging (MRSI) protocol for quantitative muscle imaging.
  2. To provide a proof of principle in Duchenne Muscular Dystrophy (DMD) that simultaneous MRI/MRSI can be used as a biomarker to monitor therapeutic efficacy in clinical trials in neuromuscular diseases.
  3. To develop a novel simultaneous Positron Emission Tomography (PET)/MRI technology to advance innovative drug development programmes for personalised medicines based on Antisense Oligonucleotide technology.

Funder: EU FP7-HEALTH-2013-INNOVATION-1
Grant value : €6m
Project length 4yr

Project Partners

Newcastle University
Leiden University
UCSCUZ Leuven
UCL
IOM
Prosensa
CRIS
SCITO

 
09 Feb 2018